Is transketolase-like protein, TKTL1, transketolase?
نویسندگان
چکیده
منابع مشابه
Retracted manuscript: Overexpression of transketolase protein TKTL1 is associated with occurrence and progression in nasopharyngeal carcinoma.
Reason: In the process of investigating an accusation of misconduct in the above manuscript, the Editors have found significant evidence of fraud perpetrated by some of the authors. 1) Dr. Wei Jia Kong’s name was used as the corresponding author without his knowledge or consent. Furthermore, Dr. Cai Pengcheng was unaware of his status as an author of the manuscript. 2) A fake email address for ...
متن کاملTransketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells.
Cancer cells display high rates of aerobic glycolysis, a phenomenon known as the Warburg effect. Lactate and pyruvate, the end products of glycolysis, are overproduced by cancer cells even in the presence of oxygen. The pentose phosphate pathway (PPP) allows glucose conversion to ribose for nucleic acid synthesis, glucose degradation to lactate, and regeneration of redox equivalents. The nonoxi...
متن کاملMutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer.
Transketolase proteins or transketolase enzyme activities have been related to neurodegenerative diseases, diabetes, and cancer. Transketolase enzyme variants and reduced transketolase enzyme activities are present in patients with the neurodegenerative disease Wernicke-Korsakoff syndrome. In Alzheimer's disease patients transketolase protein variants with different isoelectric points or a prot...
متن کاملA Δ38 Deletion Variant of Human Transketolase as a Model of Transketolase-Like Protein 1 Exhibits No Enzymatic Activity
Besides transketolase (TKT), a thiamin-dependent enzyme of the pentose phosphate pathway, the human genome encodes for two closely related transketolase-like proteins, which share a high sequence identity with TKT. Transketolase-like protein 1 (TKTL1) has been implicated in cancerogenesis as its cellular expression levels were reported to directly correlate with invasion efficiency of cancer ce...
متن کاملExpression of the mutated transketolase TKTL1, a molecular marker in gastric cancer.
The nonoxidative pentose phosphate pathway allows glucose conversion to ribose for DNA or RNA synthesis and glucose degradation to lactate controlled by transketolase enzyme reactions. It has been postulated, that this pathway is of the utmost importance in tumors for the proliferation process. We detected a strong upregulation of the mutated transketolase transcript (TKTL1) in a considerable n...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2013
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2012.12.004